Welcome to LuminoGenomics Lab!
Chemogenomics was the new terminology, fused with two different science fields which were chemistry and genomics. It used to be defined as the study of genomic responses to chemical compounds. The goal is the rapid identification of novel drugs and drug targets embracing multiple early phase drug discovery technologies following target identification and validation process. Based on our laboratory experience in Chemogenomic research, we now want to explore new types of chemistry and biological fusion field, so called “LuminoGenomics” which is from the two components the Luminescence dye chemistry and Genomics.
Luminescence or fluorescence dye in the life sciences is used generally as a non-destructive way of tracking or analysis biological molecules by means of the luminescent emission at a specific frequency, there is no background from the excitation light. Generally it was used as a conjugated label with protein or small molecule which doesn’t give any additive biological function.But in fact dye, itself is also small molecule chemical which can interact with some kinds of biological partner and possibly provides its perturbation result as a phenotype. We want to focus on the dye’s interference with biosystem and pursuing its counter partner in the process of simplified target ID and VD.
LuminoGenomics consist of three components; Luminescence (fluorescence) library, Image screening, and Proteomics. Diversity Oriented Fluorescence Library(DOFL) is the most important platform of our research which has been constructed for 3 years incorporating BODIPY, Cyanine, Styren, Rodamine, Rosamine, Chanlcone, and Fluorescein. Such a diverse structure of DOFL can give a huge discrimination of interference with cell partner which is screened by Image Screening resulting on direct simplified separation by western blot without extra tagging system. With such a beauty, proteomic analysis could be the straight forward procedure for identification of binding partner.
Click to watch the introduction video.
Further information
You can find more information on our biological research at Lab of Bioimaging Probe Development (LBPD) page in Singapore BioImaging Consortium (SBIC) site.