Publications (* as PI or corresponding author)

  1. Discerning the chemistry in individual organelles with small molecule fluorescent probes, Xu, W.; Zeng, Z.; Jiang, J. H.*; Chang, Y. T.*; Yuan, L.* Angew. Chem., Int. Ed. Engl. 2016, 55, in press.

  2. Boronic acid: a bio-inspired strategy to increase the sensitivity and selectivity of fluorescent NADH probe, Wang, L; Zhang, J.; Kim, B.; Peng, J.; Berry, S. N.; Ni, Y.; Su, D.; Lee, J.; Yuan, L.; Chang, Y. T.* J. Am. Chem. Soc. 2016, 138, in press.

  3. Development of background-free tame fluorescent probes for intracellular live cell imaging, Alamudi, S. H.; Satapathy, R.; Kim, J.; Su, D.; Ren, H.; Das, R.; Hu, L.; Alvarado-Martínez, E.; Lee, J. Y.; Hoppmann, C.; Peña-Cabrera, E.; Ha, H. H.; Park, H. S.*; Wang, L.*; Chang, Y. T.* Nat. Commun. 2016, 7: 11964. (full article)

  4. Direct organelle thermometry with fluorescence lifetime imaging microscopy in single myotubes, Itoh, H.; Arai, S.; Sudhaharan, T.; Lee, S. C.; Chang, Y. T.; Ishiwata, S.; Suzuki, M.; Lane, E. B. Chem. Commun. 2016, 52, 4458-4461. (pdf) (SI)(Back Cover)

  5. Diradical Approach towards BODIPY Based Near-infrared Dyes with Intense Absorption around 1100 nm, Ni, Y.; Lee, S.; Son, M.; Aratani, N.; Ishida, M.; Samanta, A.; Yamada, H.; Chang, Y. T.; Furuta, H.; Kim, D.; Wu, J. Angew. Chem., Int. Ed. Engl. 2016, 55, 2815-2819. (pdf) (SI)

  6. Multisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells, Wang, L.; Yuan, L.; Zeng, X.; Peng, J.; Ni, Y.; Er, J. C.; Xu, W. Agrawalla, B. K.; Su, D.; Kim, B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl. 2016, 55, 1773-1776. (pdf) (SI)

  7. Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11, Kim, J. Y.; Sahu, S.; Yau, Y. H.; Wang, X.; Shochat, S. G.; Nielsen, P. H.; Dueholm, M. S.; Otzen, D. E.; Lee, J.; Delos Santos, M. M.; Yam, J. K.; Kang, N. Y.; Park, S. J.; Kwon, H.; Seviour, T. W.; Yang, L.; Givskov, M.; Chang, Y. T.* J. Am. Chem. Soc. 2016, 138, 402-407. (pdf) (SI)

  8. Development of highly selective, sensitive and fast response upconversion luminescent platform for hydrogen sulfide detection, Peng, J.; Teoh, C. L.; Zeng, X.; Samanta, A.; Wang, L.; Xu, W.; Su, D.; Yuan, L.*, Liu, X.; Chang, Y. T.* Adv. Funct. Mat. 2016, 26, 191-199. (pdf) (SI)(Inside Back Cover)

  9. Axon-First Neuritogenesis on Vertical Nanowires, Kang, K.; Park, Y. S.; Park, M.; Jang, M. J.; Kim, S. M.; Lee, J.; Choi, J. Y.; Jung, D. H.; Chang, Y. T.; Yoon, M. H.; Lee, J. S.; Nam, Y.; Choi, I. S. Nano Lett. 2016, 16, 675-680. (pdf) (SI)

  10. Thermosensitive nanoplatforms for photothermal release of cargo from liposomes under intracellular temperature monitoring, Arai, S.; Lee, C. L. K. ; Chang, Y. T.; Satoe, H.; Sou, K. RSC Adv. 2015, 5, 93530-93538. (pdf)

  11. Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells, Kim, E. S; Samanta, A.; Cheng, H. S; Ding, Z.; Han, W.; Toschi, L.; Chang, Y. T.* Mol. Biosyst. 2015, 11, 3378-3386. (pdf) (SI)

  12. Chemical Fluorescent Probe for Detection of Aβ Oligomers, Teoh, C. L.; Su, D.; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.*; Wisniewski, T.*; Chang, Y. T.* J. Am. Chem. Soc. 2015, 137, 13503-13509. (pdf) (SI) (Spotlights) (Cover Page)

  13. A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells, Chandran, Y.; Kang, N. Y.; Park, S. J.; Husen, A. S.; Kim, J. Y.; Sahu, S.; Su, D.; Lee, J.; Vendrell, M.*; Chang, Y. T.* Bioorg. Med. Chem. Lett. 2015, 25, 4862-4865.(pdf) (SI)

  14. Identification of disulfide crosslinked tau dimer responsible for tau propagation, Kim, D.; Lim, S.; Haque, M. M.; Ryoo, N.; Hong, H. S; Rhim, H.; Lee, D.E.; Chang, Y. T.; Lee, J. S.; Cheong, E.; Kim, D. J.; Kim, Y. K. Sci. Rep. 2015, 5, 15231. (pdf) (SI)

  15. NeuO for Neuronal Labeling in Zebrafish, Teoh, C. L.; Er, J. C.; Mukherjee, P.; Chang, Y. T.* Tomography 2015, 1, 30-36. (pdf)

  16. Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes, Arora, P.; Kharkwal, S. S.; Ng, T. W.; Kunnath-Velayudhan, S.; Saini, N. K.; Johndrow, C. T.; Chang, Y. T.; Besra, G. S.; Porcelli, S. A. Chem. Phys. Lipids 2015, 191, 75-83. (pdf)

  17. Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation, Marino, A.; Arai, S.; Hou, Y.; Sinibaldi, E.; Pellegrino, M.; Chang, Y. T.; Mazzolai, B.; Mattoli, V.; Suzuki, M.; Ciofani, G. ACS Nano 2015, 9, 7678-7689. (pdf) (SI) (SI movie 1) (SI movie 2)

  18. Voices of chemical biology, Bertozzi, C. R.; Stockwell, B. R.; Kubicek, S.; Dickinson, B. C.; Chang, C. J.; Schultz, C.; Silver, P. A.; Gestwicki, J. E.; Chiosis, G.; Chattopadhyay, A.; Butcher, R. A.; Park, S. B.; Shoichet, B. K.; Flitsch, S.; Zhang, J.; Liu, D. R.; Ohnishi, Y.; Weerapana, E.; Williams, A. H.; He, C.; Moroni, A.; Thiel, G.; Chang, Y. T.; Waldmann, H.; Bogyo, M.; Oddershede, L. B.; Christopoulos, A.; Imperiali, B.; Ehrlich, H.; Chen, X.; Prescher, J. A. Nat. Chem. Biol. 2015, 11, 378-379. (pdf)

  19. Suppression of the TRIF-dependent signaling pathway of Toll-like receptor by CDr10b in RAW264.7 macrophages, Gu, G. J.; Ahn, S. I.; Kim, J. S.; Hong, C. Y.; Lee, S. C.; Chang, Y. T.; Choi, T. H.; Kim, B. S.; Youn, H. S. Int. Immunopharmacol. 2015, 28, 29-33. (pdf)

  20. A Mitochondria-Targeted Ratiometric Fluorescent Probe to Monitor Endogenously Generated Sulfur Dioxide Derivatives in Living Cells, Wang, X.; Chai, L. T.; Peng, J.; Su, D.; Yuan, L.*; Chang, Y. T.* Biomaterials 2015, 56, 1-9. (pdf) (SI)

  21. Development of nucleus staining fluorescent probe for dynamic mitosis imaging in live cells, Ghosh, K. K.; Jeong, Y. M.; Kang, N. Y.; Lee, J. Y.; Wan, S. Y.; Kim, J. Y.; Yoo, J.; Kim, D.; Kim, Y. K.*; Chang, Y. T.* Chem. Commun. 2015, 51, 9336-9338. (pdf) (SI)

  22. Development of Targetable Two-Photon Fluorescent Probes to Image Hypochlorous Acid in Mitochondria and Lysosome in Live Cell and Inflamed Mouse Model, Yuan, L.; Wang, L.; Agrawalla, B. K.; Park, S. J.; Zhu, H.; Sivaraman, B.; Peng, J.; Xu, Q. H.; Chang, Y. T.* J. Am. Chem. Soc. 2015, 137, 5930-5938. (pdf) (SI)

  23. Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient, Arai, S.; Suzuki, M.; Park, S. J.; Yoo, J. S.; Wang, L.; Kang, N. Y.; Ha, H. H.; Chang, Y. T.* Chem. Commun. 2015, 51, 8044-8047. (pdf) (SI)

  24. Glucagon-Secreting Alpha Cell Selective Two-Photon Fluorescent Probe TP-α: For Live Pancreatic Islet Imaging, Agrawalla, B. K.; Chandran, Y.; Phue, W. H.; Lee, S. C.; Jeong, Y. M.; Wan, S. Y.; Kang, N. Y.*; Chang, Y. T.* J. Am. Chem. Soc. 2015, 137, 5355-5362. (pdf) (SI) (SI movie)

  25. New Targets of Molecular Imaging in Atherosclerosis: Prehension of Current Status, Park, S. J.; Kim, J. Y.; Teoh, C. L.; Kang, N. Y.; Chang, Y. T.* Anal. Sci. 2015, 31, 245-255. (pdf)

  26. Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach, Zhang, L.; Er, J. C.; Li, X.; Heng, J. J.; Samanta, A.; Chang, Y. T.; Lee, C. L. Chem. Commun. 2015, 51, 7386-7389. (pdf)(SI)

  27. Diversity oriented approach for chemical biology, Lee, J. S.; Lee, J. W.; Kang, N.; Ha, H. H.*; Chang, Y. T.* Chem. Rec. 2015, 15, 495-510. (pdf)

  28. Solid-phase synthesis of combinatorial 2,4-disubstituted-1,3,5-triazine via amine nucleophilic reaction, Moon, S. W.; Ham, J.; Chang, Y. T.; Lee, J. W. Bull. Kor. Chem. Soc. 2015, 36, 435-438. (pdf) (SI)

  29. Cell specific imaging probe development and biomedical applications, Kang, N. Y.; Chang, Y. T.* in “5th International Conference on Biomedical Engineering in Vietnam”, pp 211-214, Eds. V. Van Toi and T. H. Lien Phung, Springer: Switzerland, 2015. (pdf)

  30. Rootin, a compound that inhibits root development through modulating PIN-mediated auxin distribution, Jeong, S.; Kim, J. Y.; Choi, H.; Kim, H.; Lee, I.; Soh, M. S.; Nam, H. G.; Chang, Y. T.*; Lim, P. O.*; Woo, H. R.* Plant Sci. 2015, 233, 116-126. (pdf) (SI)

  31. The development of a highly photostable and chemically stable zwitterionic near-infrared dye for imaging applications, Su, D.; Teoh, C. L.; Samanta, A.; Kang, N. Y.; Park, S. J.; Chang, Y. T.* Chem. Commun. 2015, 51, 3989-3992. (pdf) (SI)

  32. Synthesis and systematic evaluation of dark resonance energy transfer (DRET)-based library and its application in cell imaging, Su, D.; Teoh, C. L.; Kang, N. Y.; Yu, X.; Sahu, S.; Chang, Y. T.* Chem. Asian J. 2015, 10, 581-585. (pdf) (SI)

  33. CDy6, a photostable probe for long-term real-time visualization of mitosis and proliferating cells, Jeong, Y. M.; Duanting, Z.; Hennig, H.; Samanta, A.; Agrawalla, B. K.; Bray, M. A.; Carpenter, A. E.; Chang, Y. T.* Chem. Biol. 2015, 22, 299-307. (pdf) (SI) (SI movie 1) (SI movie 2)

  34. New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging, Ramya, A.; Samanta, A.; Nisha, N.; Chang, Y. T.; Maiti, K. K. Nanomedicine 2015, 10, 561-571. (pdf) (SI)

  35. NeuO: a fluorescent chemical probe for live neuron labeling, Er, J. C.; Leong, C.; Teoh, C. L.; Yuan, Q.; Merchant, P.; Dunn, M.; Sulzer, D.; Sames, D.; Bhinge, A.; Kim, D.; Kim, S. M.; Yoon, M. H.; Stanton, L. W.; Je, S. H.; Yun, S. W.*; Chang, Y. T.* Angew. Chem., Int. Ed. Engl. 2015, 54, 2442-2446. (pdf) (SI) (SI movie 1) (SI movie 2) Highlighted at "A library of bright ideas, C&En News 2015, 93(12), p39-40 "

  36. High-efficiency in vitro and in vivo detection of Zn2+ by dye-assembled upconversion nanoparticles, Peng, J.; Xu, W.; Teoh, C. L.; Han, S.; Kim, B.; Samanta, A.; Er. J. C.; Wang, L.; Yuan, L.; Liu, X.; Chang, Y. T.* J. Am. Chem. Soc. 2015, 137, 2336-2342. (pdf) (SI) (SI movie)

  37. The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish, Sander, V.; Patke, S. V.; Sahu, S.; Teoh, C. L.; Peng, P.; Chang, Y. T.; Davidson, A. J. Chem. Commun. 2015, 51, 395-398. (pdf) (SI)

  38. Sensitive multiplex detection of serological liver cancer biomarkers using SERS active photonic crystal fiber probe, Dinish, U. S; Balasundaram, G.; Chang, Y. T.; Olivo, M. J. Biophotonics 2014, 7, 956-965. (pdf) (SI)

  39. Dark to light! A new strategy for large Stokes shift dyes: coupling of a dark donor with tunable high quantum yield acceptors, Su, D. D.; Oh, J.; Lee, S. C.; Lim, J. M.; Sahu, S.; Yu, X.; Kim, D.*; Chang, Y. T.* Chem. Sci. 2014, 5, 4812-4818. (pdf) (SI)

  40. Chemical targeting of GAPDH moonlighting function in cancer cells reveals its role in tubulin regulation, Jung, D. W.; Kim, W. H.; Seo, S.; Oh, E.; Yim, S. H.; Ha, H. H.; Chang, Y. T.; Williams, D. R. Chem. Biol. 2014, 21, 1533-1545. (pdf) (SI)

  41. Investigating fluorescent dyes in fluorescence-assisted screening, Jee, J. E.; Lim, J.; Hyun, H.; Oon, J.; Ong, Y. S.; Massif, C.; Chang, Y. T.; Choi, H. S.; Lee, S. S. Chem. Commun. 2014, 50, 15220-15223. (pdf) (SI)

  42. A molecular fluorescent probe for targeted visualization of temperature at the endoplasmic reticulum, Arai, S.; Lee, S. C.; Zhai, D.; Suzuki, M.; Chang, Y. T.* Sci. Rep. 2014, 4, 6701. (pdf) (SI picture) (SI movie) Highlighted at "My Navi News, 2014 (Oct 23)"

  43. CDr10b inhibits the expression of cyclooxygenase-2 and inducible nitric oxide synthase induced by lipopolysaccharide, Gu, G. J.; Lim, S. J.; Ahn, S. I.; Lee, S. C.; Chang, Y. T.; Choi, T. H.; Kim, B. S.; Eom, Y. B.; Lee, N. K.; Youn, H. S. Eur. J. Pharmacol. 2014, 742, 42-46. (pdf)

  44. In Situ Investigation of Mammalian Inorganic Polyphosphate Localization Using Novel Selective Fluorescent Probes JC-D7 and JC-D8, Angelova, P. R.; Agrawalla, B. K.; Elustondo, P. A.; Gordon, J.; Shiba, T.; Abramov, A. Y.; Chang, Y. T.*; Pavlov, E. V.* ACS Chem Biol. 2014, 9, 2101-2110. (pdf) (SI)

  45. An artificial tongue fluorescent sensor array for identification and quantitation of various heavy metal ions, Xu, W.; Ren, C.; Teoh, C. L.; Peng, J.; Gadre, S. H.; Rhee, H. W.*; Lee, C. L. K.*; Chang, Y. T.* Anal. Chem. 2014, 86, 8763-8769. (pdf) (SI)

  46. Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking, Haque, M. M.; Kim, D.; Yu, Y. H.; Lim, S.; Kim, D. J.; Chang, Y. T.; Ha, H. H.; Kim, Y. K. Amyloid 2014, 21, 185-190. (pdf) (SI)

  47. Milk quality control: instant and quantitative milk fat determination with a BODIPY sensor-based fluorescence detector, Xu, W.; Bai, J.; Peng, J.; Samanta, A.; Divyanshu; Chang, Y. T.* Chem. Commun. 2014, 50, 10398-10410. (pdf) (SI) Highlighted at "CHEMISTRYWORLD, 2014 (Aug 24)" and other media at 1 2 3 4 5 6 7 8

  48. In vivo detection of macrophage recruitment in hind-limb ischemia using a targeted near-infrared fluorophore, Yoo, J. S.; Das, R. K.; Jow, Z. Y.; Chang, Y. T.* Plos One 2014, 9, e103721. (pdf) (SI)

  49. A fluorescent probe for imaging symmetric and asymmetric cell division in neurospher formation, Yun, S. W.; Leong, C.; Bi, X.; Ha, H. H.; Yu, Y. H.; Tan, Y. L.; Narayanan, G.; Sankaran, S.; Kim, J. Y.; Hariharan, S.; Ahmed, S.*; Chang, Y. T.* Chem. Commun. 2014, 50, 7492-7494. (pdf) (SI)

  50. A macrophage uptaking near-infrared chemical probe for in vivo imaging of inflammation, Kang, N. Y.; Park, S. J.; Ang, X. W.; Samanta, A.; Driessen, W. H.; Ntziachristos, V.; Vasquez, K. O.; Peterson, J. D.; Yun, S. W.*; Chang, Y. T.* Chem. Commun. 2014, 50, 6589-6591. (pdf) (SI)

  51. Live cells imaging using a turn-on FRET-based BODIPY probe for biothiols, Su, D.; Teoh, C. L.; Sahu, S.; Das, R. K.; Chang, Y. T.* Biomaterials 2014, 35, 6078-6085. (pdf) (SI)

  52. Biocompatible surface-enhanced Raman Scattering nanotags for in vivo cancer detection, Samanta, A.; Jana, S.; Chang, Y. T.* Nanomedicine 2014, 9, 523-535. (pdf)

  53. Multiplexing SERS nanotags for the imaging of differentiated mouse embryonic stem cells (mESC) and detection of teratoma in vivo, Samanta, A.; Das, R. K.; Park, S. J.; Maiti, K. K.; Chang, Y. T.* Am. J. Nucl. Med. Mol. Imaging 2014, 4, 114-124. (pdf)

  54. A Chemical Probe Selective for Human Pluripotent Stem Cells, Hirata, N.; Nakagawa, M.; Fujibayashi, Y.; Yamauchi, K.; Murata, A.; Minami, I.; Tomioka, M.; Kondo, T.; Kuo, T. F.; Endo, H.; Inoue, H.; Sato, S. I.; Ando, S.; Kawazoe, Y.; Aiba, K.; Nagata, K.; Kawase, E.; Chang, Y. T.; Suemori, H.; Eto, K.; Nakauchi, H.; Yamanaka, S.; Nakatsuji, N.; Ueda, K.; Uesugi1, M. Cell Rep. 2014, 6, 1165-1174. (pdf) (SI)

  55. Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses, Park, S. J.; Yeo, H. C.; Kang, N Y.; Kim, H. J.; Lin, J.; Ha, H. H.; Vendrell, M.; Lee, J. S.; Chandran, Y.; Lee, D. Y.*; Yun, S. W.*; Chang, Y. T.* Stem Cell Res. 2014, 12, 730-741. (pdf) (SI1)(SI2)(SI3)

  56. Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development, Yun, S. W.; Kang, N. Y.; Park, S. J.; Ha, H. H.; Kim, Y. K.; Lee, J. S.; Chang, Y. T.* Acc. Chem. Res. 2014, 47, 1277-1286. (pdf)

  57. The role of “disaggregation” in optical probe development, Zhai, D.; Xu, W.; Zhang, L.; Chang, Y. T.* Chem. Soc. Rev. 2014, 43, 2402-2411. (pdf)

  58. Wavelength and shape dependent SERS study to develop ultrasensitive nanotags for imaging of cancer cells, Samanta, A.; Jana, S.; Das, R. K.; Chang, Y. T.* RSC Adv. 2014, 4, 12415-12421. (pdf) (SI)

  59. “Orange Alert”: A fluorescent detector for bisphenol A in water environments, Zhang, L.; Er, J. C.; Xu, W.; Qin, X.; Samaanta, A.; Jana, S.; Lee, C. L. K.; Chang, Y. T.* Anal. Chim. Acta 2014, 815, 51-56. (pdf) (SI)

  60. meso-Ester and carboxylic acid substituted BODIPYs with far-red and near-infrared emission for bio-imaging applications, Ni, Y.; Zeng, L.; Kang, N. Y.; Huang, K. W.; Wang, L.; Zeng, Z.; Chang, Y. T.*; Wu, J.* Chem. Eur. J. 2014, 20, 2301-2310. (pdf) (SI)

  61. Actively targeted in vivo multiplex detection of intrinsic cancer biomarkers using biocompatible SERS nanotags, Dinish, U. S.; Balasundaram, G.; Chang, Y. T.; Olivo, M. Sci. Rep. 2014, 4, 4075. (pdf) (SI)

  62. Discovery of a structural-element specific G-quadruplex “Light-Up” probe, Zhang, L.; Er, J. C.; Ghosh, K. K.; Chung, W. J.; Yoo, J.; Xu, W.; Zhao, W.; Phan, A. T.; Chang, Y. T.* Sci. Rep. 2014, 4, 3776. (pdf) (SI)

  63. Development of a fluorescent sensor for an illicit date rape drug-GHB, Zhai, D.; Tan, Y. Q. E.; Xu, W.; Chang , Y. T.* Chem. Commun. 2014, 50, 2904-2906. (pdf) (SI)(Highlights)

  64. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens, Arora, P.; Baena, A.; Yu, K. O. A.; Saini, N. K.; Kharkwal, S. S.; Goldberg, M. F.; Kunnath-Velayudhan, S.; Carreño, L. J.; Venkataswamy, M. M.; Kim, J.; Lazar-Molnar, E.; Lauvau, G.; Chang, Y. T.; Liu, Z.; Bittman, R.; Al-Shamkhani, A.; Cox, L. R.; Jervis, P. J.; Veerapen, N.; Besra, G. S; Porcelli, S. Immunity 2014, 40, 105-116. (pdf) (SI)

  65. A macrophage-specific fluorescent probe for intraoperative lymph node staging, Yoo, J. S.; Lee, S. C.; Jow, Z. Y.; Koh, P. Y. X.; Chang, Y. T.* Cancer Res. 2014, 74, 44-55. (pdf) (SI)

  66. Microglia specific fluorescent probe for live cell imaging, Leong, C.; Lee, S. C.; Ock, J.; See, P.; Park, S. J.; Ginhoux, F.; Yun, S. W.*; Chang, Y. T.* Chem. Commun. 2014, 50, 1089-1091. (pdf) (SI-1, SI-2, Movie)

  67. Ratiometric fluorescent probes for hydrogen peroxide from a focused library, Lee, H. W.; Rhee, H. W.; Chang, Y. T.; Hong J. I. Chem. Eur. J. 2013, 19, 14791-14794.(pdf) (SI)

  68. Forward chemical genetic screening, Choi, H.; Kim, J. Y.; Chang Y. T.*; Nam, H. G.* Methods Mol. Biol. 2013, 1062, 393-404.(pdf)

  69. Neural stem cell isolation from the whole mouse brain using the novel FABP7-binding fluorescent dye, CDr3, Leong, C.; Zhai, D.; Kim, B.; Yun, S. W.*; Chang, Y. T.* Stem Cell Res. 2013, 11, 1314-1322.(pdf) (SI)

  70. Focused fluorescent probe library for metal cations and biological anions, Rhee, H. W.; Lee, S. W.; Lee, J. S.; Chang, Y. T.*; Hong, J. I.* ACS Comb. Sci. 2013, 15, 483-490.(pdf) (SI)

  71. A fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin, Er, J. C.; Vendrell, M.; Tang, M. K.; Zhai, D.; Chang, Y. T.* ACS Comb. Sci. 2013, 15, 452-457.(pdf) (SI) (WITH COVER PAGE)

  72. Visualization and isolation of Langerhans islets by fluorescent probe PiY, Kang, N. Y.; Lee, S. C.; Park, S. J.; Ha, H. H.; Yun, S. W.; Kostromina, E.; Gustavsson, N.; Ali, Y.; Chandran, Y.; Chun, H. S.; Bae, M. A.; Ahn, J. H.; Han, W.; Radda, G. K.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl. 2013, 52, 8557-8560.(pdf) (SI)

  73. Make Caffeine visible: a fluorescent caffeine "traffic light" detector, Xu, W.; Kim, T. H.; Zhai, D.; Er, J. C.; Zhang, L.; Kale, A. A.; Agrawalla, B. K.; Cho, Y. K.; Chang, Y. T.* Sci. Rep. 2013, 3, 2255. (pdf) (Highlights)

  74. Ratiometric fluorescent dye for the detection of glutathione in live cell and liver cancer tissue, Zhai, D.; Lee, S. C.; Yun, S. W.; Chang, Y. T.* Chem. Commun. 2013, 49, 7207-7209.(pdf) (SI)

  75. Development of a chalcone-triazine fusion library: combination of a fluorophore and biophore, Lee, S. C.; Zhai, D.; Chang, Y. T.* Tetrahedron Lett. 2013, 54,2976-2979. (pdf) (SI)

  76. A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes, Jung, D. W.; Kim, W. H.; Park, S. H.; Lee, J.; Kim, J.; Su, D.; Ha, H. H.; Chang, Y. T.; Williams, D. R. ACS Chem. Biol. 2013, 8, 1271-1282. (pdf) (SI)

  77. The development of novel NIR tetraarylazadipyrromethene fluorescent dyes, Lee, S. C.; Zhai, D.; Mukherjee, P.; Chang, Y. T.* Materials 2013, 6, 1779-1788.(pdf) (SI)

  78. Development of fluorescent sensor for illicit date rape drug-GBL, Zhai, D.; Agrawalla, B. K.; Eng, E. S. F.; Lee, S. C.; Xu, W.; Chang, Y. T.* Chem. Commun. 2013, 49, 6170-6172.(pdf) (SI) Highlighted at "CHEMISTRYWORLD, 2013 (JUNE 26)"

  79. Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington’s disease, Im, J. K.; Kim, S. J.; Jeong, Y. H.; Kim, W.; Lee, D. H.; Lee, W. S.; Chang, Y. T.; Kim, K. T.; Chung, S. K. Med. Chem. Commun. 2013, 4, 310-316. (pdf) (SI)

  80. Surface-enhanced Raman scattering in cancer detection and imaging, Vendrell, M.; Maiti, K. K.; Dhaliwal, K.; Chang, Y. T. Trends Biotechnol. 2013, 31, 249-257. (pdf)

  81. MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes, Er, J. C.; Tang, M. K.; Chia, C. G.; Liew, H.; Vendrell, M.*; Chang, Y. T.* Chem. Sci. 2013, 4, 2168-2176. (pdf) (SI)

  82. Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1, Hawley, T. S.; Riz, I.; Yang, W.; Wakabayashi, Y.; DePalma, L.; Chang, Y. T.; Peng, W.; Zhu, J.; Hawley, R. G. Am. J. Hematol. 2013, 88, 265-272. (pdf) (SI)

  83. Discovery of a chondroitin 4-sulphate fluorescent probe, Lee, S. C.; Zhai, D.; Chang, Y. T.* Supramol. Chem. 2013, 25, 41-45. (DOI:10.1080/10610278.2012.735670)

  84. Establishment of a robust dengue virus NS3–NS5 binding assay for identification of protein–protein interaction inhibitors, Takahashi, H.; Takahashi, C.; Moreland, N. J.; Chang, Y. T.; Sawasaki, T.; Ryo, A.; Vasudevan, S. G.; b, Suzuki, Y.; Yamamoto, N. Antiviral Res. 2012, 96, 305-314. (pdf) (SI)

  85. Orally active desulfated low molecular weight heparin and deoxycholic acid conjugate, 6ODS-LHbD, suppresses neovascularization and bone destruction in arthritis, Hwang, S. R.; Seo, D. H.; Al-Hilal, T. A.; Jeon, O. C.; Kang, J. H.; Kim, S. H.; Kim, H. S.; Chang, Y. T.; Kang, Y. M.; Yang, V. C.; Byun, Y.* J. Control. Release 2012, 163, 374-384. (pdf) (SI)

  86. High-performance graphene-titania platform for detection of phosphopeptides in cancer cells, Tang, L. A. L.; Wang, J.; Lim, T. K.; Bi, X.; Lee, W. C.; Lin, Q.; Chang, Y. T.; Lim, C. T.; Loh, K. P. Anal. Chem. 2012, 84, 6693-6700. (pdf) (SI)

  87. A fluorescent screening platform for the rapid evaluation of chemicals in cellular reprogramming, Vendrell, M.; Park, S. J.; Chandran, Y.; Lee, C. L. K.; Ha, H. H.; Kang, N. Y.; Yun, S. W.; Chang, Y. T.* Stem Cell Res. 2012, 9, 185-191. (pdf) (SI)

  88. Eastern Staining: A simple recombinant protein detection technology using a small peptide tag and its orthogonal fluorescent compound, Lee, J. J.; Kim, J. Y.; Zhai, D.; Yun, S. W.; Chang, Y. T.* Interdiscip. Bio Central 2012, 4, article no. 5, doi: 10.4051/ibc.2012.3.2.0005. (pdf)

  89. Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic wnt signaling, Speese, S. D.; Ashley, J.; Jokhi, V.; Nunnari, J.; Barria, R.; Li, Y.; Ataman, B.; Koon, A.; Chang, Y. T.; Li, Q.; Moore, M. J.*; Budnik, V.* Cell 2012, 149, 832-846. (pdf)

  90. Development of fluorescent Chalcone library and its application in the discovery of a mouse embryonic stem cell probe, Lee, S. C.; Kang,N. Y.; Park, S. J.; Yun, S. W.; Chandran, Y.; Chang, Y. T.* Chem. Commun. 2012, 48, 6681-6683 (pdf) (SI)

  91. Combinatorial strategies in fluorescent probe development, Vendrell, M.*; Zhai, D.; Er, J. C. Chang, Y. T.* Chem. Rev. 2012, 112, 4491-4320 (pdf)

  92. Neural stem cell specific fluorescent chemical probe binding to FABP7, Yun, S. W.; Leong, C. K. M; Zhai, D.; Tan, Y. L.; Lim, L.; Bi, X.; Lee, J. J.; Kim, H.; Kang, N. Y.; Ng, S. H.; Stanton, L. W.; Chang, Y. T.* Proc. Natl. Acad. Sci. USA 2012, 109, 10214-10217 (pdf) (SI)

  93. Imaging Histamine in Live Basophils and Macrophages with a Fluorescent Mesoionic Acid Fluoride, Kielland, N.; Vendrell, M.; Lavilla, R.*; Chang, Y. T.* Chem. Commun. 2012, 48, 7401-7403 (pdf) (SI)

  94. Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production, Kim, J. Y. H.; Lee, J. W.; Lee, W. S.; Ha, H. H.; Vendrell, M.; Bork, J. T.; Lee, Y. S.*; Chang, Y. T.* ACS Comb. Sci. 2012, 14, 395−398. (pdf) (SI)

  95. A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening, Jung, D. W.; Oh, E. S.; Park, S. H.; Chang, Y. T.; Kim, C. H.; Choi, S. Y.; Williams, D. R.* Mol. Biosyst. 2012, 8, 1930-1939 (pdf) (SI)

  96. Multiplex Targeted in vivo Cancer Detection Using Sensitive Near-Infrared SERS Nanotags, Maiti, K. K.; Dinish, U. S.; Samanta, A.; Vendrell, M.; Soh, K. S.; Park, S. J.; Olivo, M.; Chang, Y. T.* Nano Today. 2012, 7, 85-93 (pdf) (SI)

  97. Bioimaging Probes Development by DOFLA (Diversity Oriented Fluorescence Library Approach) for in vitro, in vivo and clinical applications, Yun, S. W.; Chang, Y. T.* in ìAdvances in Bio-Imaging: From Physics to Signal Understanding Issuesî, Eds. LomÈnie, Nicolas; Racoceanu, Daniel; Gouaillard, Alexandre, in State-of-the-Art and Challenges Series: Advances in Intelligent and Soft Computing, Springer. 2012, 120, 55-66 (pdf)

  98. Diversity Oriented Fluorescence Library Approach for Stem Cell Probe Development, Yun, S. W.; Kang, N. Y.; Chang, Y. T.* in ìStem Cells and Cancer Stem Cellsî, pp 7-14, Ed. Hayat, M. A., Therapeutic Applications in Disease and Injury, Springer. 2012, 3, 7-14 (pdf)

  99. Solid-phase synthesis of dyes and their application as sensors and bioimaging probes, Vendrell, M.; Ha, H. H.; Lee, S. C.; Chang, Y. T.* in ìSolid-Phase Organic Synthesis: Concepts, Strategies, and Applicationsî, pp 427-440, Eds. Toy P. and Lam Y.,Wiley-WCH. 2012, 14, 427-440 (pdf)

  100. Identification of cancer cell-line origins using fluorescence image-based phenomic screening, Lee, J. S.; Kim, Y. K.; Kim, H. J.; Hajar, S.; Tan, Y. L.; Kang, N. Y.; Ng, S. H.; Yoon, C. N.; Chang, Y. T.* PLoS One. 2012, 7, e32096 (pdf)

  101. High content live cell imaging for the discovery of new antimalarial marine natural products, Cervantes, S.; Stout, P. E.; Prudhomme, J.; Engel, S.; Bruton, M.; Cervantes, M.; Carter, D.; Chang, Y. T.; Hay, M. E.; Aalbersberg, W.; Kubanek, J.; Le Roch, K. G.* BMC Infect. 2012, 12, 1-9 (pdf)

  102. Identification of fluorescent compounds with non-specific binding property via high throughput live cell microscopy, Nath, S.; Spencer, V. A.; Han, J.; Zhang, K.; Fontenay, G. V.; Anderson, C.; Hyman, J. M.; Nilsen-Hamilton, M.; Chang, Y. T.; Parvin, B.* PLoS One. 2012, 7, e28802 (pdf)

  103. Synthesis of a Novel BODIPY Library and Its Application in the Discovery of a Fructose Sensor, Zhai, D.; Lee, S. C.; Vendrell, M.; Leong, L. P.; Chang, Y. T.* Acs. Comb. Sci. 2012, 14, 81-84 (pdf) (SI)

  104. Intracellular glutathione detection using MnO2-nanosheet modified upconversion nanoparticles, Deng, R.; Xie, X.; Vendrell, M.; Chang, Y. T.; Liu, X.* J. Am. Chem. Soc. 2011, 133, 20168-20171 (pdf) (SI)

  105. A triazine compound S06 inhibits pro-invasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90, Jung, D. W.; Kim, J.; Che, Z. M.; Oh, E. S.; Eom, S. H.; Im, S. H.; Ha, H. H.; Chang, Y. T.; Williams, D. R.*; Kim, J.* Chem. Biol. 2011, 18, 1581-1590. (pdf)

  106. Bioimaging of stem cells, live tissue and whole animals using Diversity Oriented Fluorescence Library Approach, Chang, Y. T.* “The Primo Vascular System: Its Role in Cancer and Regeneration” 2011, Ed. K. S. Soh, K. A. Kang, and D. K. Harrison, 285-289. (pdf)

  107. Embryonic and induced pluripotent stem cell staining and sorting using live cell fluorescence imaging probe CDy1, Kang, N. Y.; Yun, S. W.; Ha, H. H.; Park, S. J.; Chang, Y. T.* Nat. Protoc. 2011, 6, 1044-1052. (pdf)

  108. Diversity-oriented optical imaging probe development, Lee, J. S.; Vendrell, M.; Chang, Y. T.* Curr. Opin. Chem. Biol. 2011, 15, 760-767. (pdf)

  109. Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor, Vendrell, M.; Krishna, G.G.; Ghosh, K. K.; Zhai, D.; Lee, J. S.; Zhu, Q.; Yau, Y. H.; Shochat, S. G.; Kim, H.; Chung. J.; Olivo, M.; Chang, Y. T.* Chem. Commun., 2011, 47, 8424-8426. (pdf) (SI)

  110. Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Detection, Samanta, A.; Maiti, K. K.; Soh, K. S.; Liao, X.; Vendrell, M.; Dinish, U. S.; Yun, S. W.; Bhuvaneswari, R.; Kim, H.; Rautela, S.; Chung, J.; Olivo, M.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2011, 50, 6089-6092. (pdf) (SI)

  111. Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues, Wang, S.; Lee, W. S.; Ha, H. H.; Chang, Y. T.* Org. Biomol. Chem., 2011, 9, 6924-6926. (pdf) (SI)

  112. Solid phase synthesis of ultra-photostable cyanine NIR dy, Das, R. K.; Samanta, A.; Ha, H. H.; Chang, Y. T.* RSC Adv., 2011, 1, 573-575. (pdf) (SI)

  113. Development of a High Affinity Inhibitor of the Prostaglandin Transporter PGT, Chi, Y.; Min, J.; Jasmin, J. F.; Lisanti, M. P.; Chang, Y. T.; Schuster, V. L.* J. Pharmacol. Exp. Ther., 2011, 339, 633-641.(pdf)

  114. Styryl-Based and Tricyclic Compounds as Potential Anti-Prion Agents,Chung, E.; Prelli, F.; Dealler, S.; Lee, W. S.; Chang, Y. T.; Wisniewski, T.* PlosOne., 2011, 6, e24844. (pdf)

  115. Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging, Lee, J. H.; So, J. H.; Jeon, J. H.; Choi, E. B.; Lee, U. R.; Chang, Y. T.; Kim, C. H.; Bae, M. A.; Ahn, J. H. Chem. Commun. 2011, 47, 7500-7502. (pdf) (SI)

  116. Development of Intravascular Contrast Agents for MRI Using Gadolinium Chelates, Kittigowittana, K.; Yang, C. T.; Cheah, W. C.; Chuang, K. H.; Tuang, C. Y.; Chang, Y. T.; Golay, X.; Bates, R. W. ChemMedChem 2011, 6, 781-787. (pdf) (SI)

  117. Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain, Kim, Y. K.; Lee, J. K.; Lee, J. S.; Yoon, C. N.; Chang, Y. T.* Mol. Biosyst. 2011, 7, 2375-2378. (pdf) (SI)

  118. Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe, Ghosh, K. K.; Ha, H. H.; Kang, N. Y.; Chandran, Y.; Chang, Y. T.* Chem. Commun. 2011, 47, 7488-7490. (pdf) (SI)

  119. Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging, Vendrell, M,; Samanta, A.; Yun, S. W.; Chang, Y. T.* Org. Biomol. Chem. 2011, 9, 4760-4762. (pdf) (SI)

  120. Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach, Kang, N. Y.; Ha, H. H.; Yun, S. W.; Yu, Y. H.; Chang, Y. T.* Chem. Soc. Rev. 2011, 40, 3613-3626. (pdf)

  121. Recapture of GFP Chromophore Fluorescence in a Protein Host, Baldridge, A.; Feng, S.; Chang, Y. T.; Tolbert, L. ACS Comb. Sci. 2011, 13, 214-217. (pdf) (SI)

  122. A Photostable Near-Infrared Protein Labeling Dye for in vivo Imaging, Samanta, A.; Vendrell, M.; Yun, S. W.; Guan, Z.; Xu, Q. H.; Chang, Y. T.* Chem. Asian J. 2011, 6, 1353-1357. (pdf) (SI)

  123. A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids, Arora, Pooja; Venkataswamy, Manjunatha; Baena, Andres; Bricard, Gabriel; Li, Qian; Veerapen, N.; Ndonye, R.; Park, J. J.; Lee, J. H.; Seo, K. C.; Howell, A.; Chang, Y. T.; Illarionov, P.; Besra, G.; Chung, S. K.; Porcelli, S. J. Am. Chem. Soc. 2011, 133, 5198-5201. (pdf) (SI)

  124. Combinatorial Solid-Phase Synthesis of 6-aryl-1,3,5-triazines via Suzuki Coupling, Lee, J. W.; Ha, H. H.; Vendrell, M.; Bork, J. T.; Chang, Y. T.* Aust. J. Chem. 2011, 64, 540-544. (pdf) (SI)

  125. Bodipy-diacrylate Imaging Probes for Targeted Proteins inside Live cells, Lee, J. J; Lee, S. C.; Zhai, D.; Ahn, Y. H.; Yeo, H. Y.; Tan, Y. L.; Chang, Y. T.* Chem. Commun. 2011, 47, 4508-4510. (pdf) (SI)

  126. A colorimetric pH indicators and boronic acids ensemble array for quantitative sugar analysis, Ghosh, K. K.; Yap, E.; Kim, H.; Lee, J.- S.; Chang, Y. T.* Chem. Commun., 2011, 47, 4001-4003. (pdf) (SI)

  127. Fluorescent labeling of membrane proteins on the surface of living cells by a self-catalytic glutathione S-transferase omega 1 tag, Lee, J. J.; Son, J.; Ha, H. H.; Chang, Y. T.* Mol. Biosyst., 2011, 7, 1270-1276. (pdf) (SI)

  128. Target Identification: A Challenging Step in Forward Chemical Genetics, Das, R. K.; Samanta, A.; Ghosh, K.; Zhai, D.; Xu, W.; Su, D.; Leong, C.; Chang, Y. T.* Interdiscip. Bio Central 2011, 3, 1-16. (link) (pdf)

  129. Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters, Maiti K. K.; Samanta, A.; Vendrell, M.; Soh, K. S.; Olivo, M.; Chang, Y. T.* Chem. Commun., 2011, 47, 3514-3516. (pdf) (SI)

  130. The binding of fluorophores to proteins depends on the cellular environment, Kim, Y. K.; Lee, J. S.; Bi, X.; Ha, H. H.; Ng, S. H.; Ahn, Y. H.; Lee, J. J.; Wagner, B. K.; Clemons, P. A.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2011, 50, 2761-2763. (pdf) (SI) (with cover page)

  131. Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects, Jung, D. W.; Ha, H. H.; Zheng, X.; Chang, Y. T.; Williams, D. R. Mol. Biosyst. 2011, 7, 346-358. (pdf) (SI)

  132. Fluorescence response profiling for small molecule sensors utilizing the green fluorescent protein chromophore and its derivatives, Lee, J. S.; Baldridge, A.; Feng, S.; Yang, S. Q.; Kim, Y. K.; Tolbert, L. M.; Chang, Y. T.* ACS Comb. Sci., 2011, 13, 32-38. (pdf) (SI)

  133. Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library, Lee, J. S.; Kim, H. K.; Feng S.; Vendrell, M.; Chang, Y. T.* Chem. Commun. 2011, 47, 2339-2341. (pdf) (SI)

  134. Combinatorial search of sensors, Vendrell, M.; Feng, S.; Chang, Y. T.* in “Chemosensors: Principles, Strategies and Application”, pp 87-106, Ed. B. Wang and E. V. Anslyn, John Wiley and Sons, 2011. (pdf)

  135. Mitochondrial Affinity of Guanidine-rich Molecular Transporters Built on myo- and scyllo-Inositol Scaffolds: Stereochemistry Dependency, Ghosh, S. C.; Kim, B.; Im, J.; Lee, W. S.; Im, C. N.; Chang, Y. T.; Kim, W.; Kim, K. T.; Chung, S. K. Bull. Kor. Chem. Soc. 2010, 31, 3623-3631. (pdf)

  136. α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents, Bricard, G.; Venkataswamy, M. M.; Yu, K. O.; Im, J. S.; Ndonye, R. M.; Howell, A. R.; Veerapen, N.; Illarionov, P. A.; Besra, G. S.; Li, Q.; Chang, Y. T.; Porcelli, S. A. PLoS One 2010, 5, e14374. (pdf)

  137. Quantitative structure-fluorescence property relationship analysis of a large BODIPY library, Schueller, A.; Goh, G. B.; Kim, H.; Lee, J. S.; Chang, Y. T.* Mol. Inf., 2010, 29717-729. (pdf) (SI)

  138. Development of photostable near-IR cyanine dyes, Samanta, A.; Vendrell, M.; Das, R.; Chang, Y. T.* Chem. Commun., 2010, 46, 7406-7408. (pdf) (SI)

  139. Development of biocompatible SERS nanotag with increased stability by chemisorptions of reporter molecule for in vivo cancer detection, Maiti, K. K.; Dinish, U. S.; Fu, C. Y.; Lee, J. J.; Soh, K. S.; Yun, S. W.; Bhuvanaeswari, R.; Olivo, M.; Chang, Y. T.* Biosens. Bioelectron., 2010, 26, 398-403. (pdf) (SI)

  140. A fluorescent rosamine compound selectively stains pluripotent stem cells, Im, C. N.; Kang, N. Y.; Ha, H. H.; Bi, X.; Lee, J. J.; Park, S. J.; Lee, S. Y.; Vendrell, M.; Kim, Y. K.; Lee, J. S.; Li, J.; Ahn, Y. H.; Feng, B.; Ng, H. H.; Yun, S. W.*; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2010, 49, 7497-7500. (pdf) (SI) Highlighted at "Fluorescence method detects stem cells, C&En News 2010, 88(38), p25"

  141. Anti-amyloidogenic effect of AA3E2 attenuates β-amyloid induced toxicity in SK-N-MC cells, Shaykhalishahi, H.; Taghizadeh, M.; Yazdanparast, R.; Chang, Y. T. Chem. Biol. Interact. 2010, 186, 16-23. (pdf)

  142. Imaging metabolic syndrome, Han, W. P.; Chuang, K. H.; Chang, Y. T.; Olivo, M.; Velan, S. S.; Bhakoo, K.; Townsend, D.; Radda, G. K. EMBO Mol. Med. 2010, 2, 196-210. (pdf)

  143. Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques, Hong, M. C.; Kim, Y. K.; Choi, J. Y; Yang, S. Q.; Rhee, H.; Ryu, Y. H.; Choi, T. H.; Cheon, G. J.; An, G. I.; Kim, H. Y.; Kim, Y.; Kim, D. J.; Lee, J. S.; Chang, Y. T.; Lee, K. C. Bioorg. Med. Chem. 2010, 18, 7724-7730.(pdf) (SI)

  144. A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration, Usher, L.; Johnstone, A.; Erturk, A.; Hu, Y.; Strikis, D.; Wanner, I.; Moorman, S.; Lee, J. W.; Min, J.; Ha, H. H.; Duan, Y.; Hoffman, S.; Goldberg, J.; Bradke, F.; Chang, Y. T.; Lemmon, V.; Bixby, J. J. Neurosci. 2010, 30, 4693-4706. (pdf) (SI).

  145. Diversity-oriented Fluorescence Library Approaches for Probe Discovery and Development, Vendrell, M.; Lee, J. S.; Chang, Y. T.* Curr. Opin. Chem. Biol. 2010, 14, 383-389. (pdf) (Movie)

  146. Discovery of Novel Zebrafish Neural Tracers by Organism-based Screening of Rosamine Library, Li, J.; Ha, H. H.; Guo, L.; Coomber, D.; Chang, Y. T.* Chem. Commun. 2010, 46, 2932-2934. (pdf) (SI).

  147. Isozyme-Specific Fluorescent Inhibitor of Glutathione S-Transferase Omega1, Son, J. H.; Lee, J. J.; Lee, J. S.; Schuller, A.; Chang, Y. T.* ACS Chem. Biol. 2010, 5, 449-453. (pdf) (SI)

  148. Control of muscle differentiation by a mitochondria-targeted fluorophore, Kim, Y. K.; Ha, H. H.; Lee, J. S.; Bi, X. Z.; Ahn, Y. H.; Hajar, S.; Lee, J. J.; Chang, Y. T.* J. Am. Chem. Soc., 2010, 132, 576-579. (pdf) (SI).

  149. Combinatorial Synthesis of Triphenylmethine Library and Their Application in the Development of Surface Enhanced Raman Scattering (SERS) Probes, Cho, S. J.; Ahn, Y. H.; Maiti, K. K.; Dinish, U. S.; Fu, C. Y.; Thoniyot, P.; Olivo, M.; Chang, Y. T.* Chem. Commun., 2010, 46, 722-724. (pdf) (SI).

  150. Discovery of a Green DNA Probe for Live-Cell Imaging, Feng, S.; Kim, Y. K.; Yang, Q.; Chang, Y. T.* Chem. Commun., 2010, 46, 436-438. (pdf) (SI)

  151. Functional profiling, identification and inhibition of plasmepsins in intraerythrocytic malaria parasites, Liu, K.; Shi, H.; Xiao, H.; Chong, A. G. L.; Bi, X.; Chang, Y. T.; Tan, K. Yada, R. Y.; Yao, S. Q. Angew. Chem., Int. Ed. Engl. 2009, 48, 8293-8297. (pdf) (SI)

  152. Colorimetric sensor array for qualitative water analysis, Chan, S. A., Lee, J. S., Chang, Y. T.* Aust. J. Chem. 2009, 62, 1040-1046. (pdf) (SI)

  153. Novel orthogonal synthesis of tagged combinatorial triazine library via Grignard reaction, Lee, J. W.; Bork, J. T. Ha, H. H.; Samanta, A.; Chang, Y. T.* Aust. J. Chem. 2009, 62, 1000-1006. (pdf) (SI)

  154. Inhibition of H2O2-induced neuroblastoma cell cytotoxicity by a triazine derivative, AA3E2, Shaykhalishahi, H.; Yazdanparast, R.; Ha, H. H.; Chang, Y. T.* Eur. J. Pharmacol. 2009, 622, 1-6 (pdf).

  155. Synthesis and cellular uptake properties of guanidine-containing molecular transporters built on sucrose scaffold, Lee, W. S.; Im, C. N.; Teng, Q. Y.; Chang, Y. T.; Kim, D. C.; Kim, K. T.; Chung, S. K*. Mol. Biosys. 2009, 5, 822-825. (pdf) (SI)

  156. Synthesis of a BODIPY Library and Its Application to the Development of Live Cell Glucagon Imaging Probe, Lee, J. S.; Kang, N. Y.; Kim, Y. K.; Samanta, A.; Feng, S.; Kim, H. K.; Vendrell, M.; Park, J. H.; Chang, Y. T.* J. Am. Chem. Soc. 2009, 131, 10077-10082. (pdf) (SI) Highlighted at "JACS Select #10: Supramolecular and Chemical Cascade Approaches to Molecular Sensing.

  157. Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation, Im, J. S.; Arora, P.; Bricard, G.; Molano, A.; Baine, I.; Jerud, E. S.; Goldberg, M. F.; Yu, K. O. A.; Howell, A. R.; Chang, Y. T.; Illarionov, P. A.; Besra, G. S.; Porcelli, S. A. Immunity, 2009, 30, 888-898. (pdf) (SI)

  158. High-content live cell imaging with RNA probes: advancements in high throughput antimalarial drug discovery, Cervantes, S.; Prudhomme, J.; Carter, D.; Krishna, G. G.; Li, Q.; Chang, Y. T., Le Roch, K. G. BMC Cell Biol. 2009, 10, 45. (pdf) (SI-1, SI-2)

  159. Diversity-Oriented Fluorescence Library Approach for Discovery of Sensors and Probe, Lee, J. S.; Kim, Y. K.; Vendrell, M.; Chang, Y. T.* Mol. Biosyst. 2009, 5, 411-421. (pdf) (with cover picture)

  160. Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes, Shedden, K.; Li, Q.; Liu F.; Chang, Y. T.; Rosania, G. Cytometry A, 2009, 75, 482-493. (pdf)

  161. Discovery of amyloid-β aggregation inhibitors using an engineered assay for intracellular protein folding and solubility, Lee, L. L.; Ha, H.; Chang, Y. T.; DeLisa, M. P. Protein Sci. 2009, 18, 277-286. (pdf)

  162. Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferators-activated receptors, Tsuji, K.; Satoh, S.; Mitsutake, S.; Murakami, I.; Park, J. J.; Li, Q.; Chang, Y. T.; Chung, S. K.; Igarashi, Y. Bioorg. Med. Chem. Lett. 2009, 19, 1643-1646. (pdf)

  163. Diversity oriented fluorescence library approach (DOFLA) for novel sensor development, Wang, S.; Chang, Y. T.* in “Combinatorial methods for chemical and biological sensors”, pp 419-440, Eds. R. A. Potyrailo and V. M. Mirsky, Springer: New York,2009. (pdf)

  164. Forward chemical genetics, Chang, Y. T.* Wiley Encyclopedia of Chemical Biology, vol 2, pp94-111, Ed. Tadhq P. Beqley, Hoboken, N.J: John Wiley & Sons, 2009. (pdf)

  165. Tagged library for chemical genetics, Chang, Y. T.* in Austin, D. (ed.), Chemical Biology: The role of Chemistry in our fundamental understanding of Biology, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London, 2008. (Online)

  166. Synthesis and anticancer activity studies of cyclopamine derivatives, Zhang, J.; Garrossian, M.; Gardner, D.; Garrossian, A.; Chang, Y. T.; Kim, Y. K.; Chang, C. W. T. Bioorg. Med. Chem. Lett. 2008, 18, 1359-1363. (pdf) (SI)

  167. Diversity oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor, Wang, S.; Kim, Y. K.; Chang, Y. T.* J. Comb. Chem.2008, 10, 460-465. (pdf) (SI)

  168. A selective human serum albumin sensor from the screening of a fluorescent rosamine library, Ahn, Y. H.; Lee, J. S.; Chang, Y. T.* J. Comb. Chem.2008, 10, 376-380. (pdf) (SI)

  169. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening, Wagner, B. K.; Carrinski, H. A.; Ahn, Y. H.; Kim, Y. K.; Gilbert, T. J.; Fomina, D. A.; Schreiber, S. L.; Chang, Y. T.; Clemons, P. A. J. Am. Chem. Soc. 2008, 130, 4208-4209. (pdf) (SI-1, SI-2)

  170. Discovery of heparin chemosensors through diversity oriented fluorescence library approach, Wang, S.; Chang, Y. T.* Chem. Commun. 2008, 1173-1175 (pdf) (SI) (with cover picture) Highlighted at "Blood sensor for safer surgery, Chemical Biology (RSC), 2008 (January 10)

  171. Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library, Park, J. J.; Li, Q.; Diaz, K.; Chang, Y. T.; Chung, S. K. Bioorg. Chem. 2008, 36, 220-228.(pdf) (SI)

  172. Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents, Zhou, C.; Min, J.; Liu, Z.; Young, A.; Deshazer, H.; Gao, T.; Chang, Y. T.; Kallenbach, N. R. Bioorg. Med. Chem. Lett. 2008, 18, 1308-1311. (pdf)

  173. Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells, Kim, D. S.; Kim, S. H.; Song, J. H.; Chang, Y. T.; Hwang, S. Y.; Kim, T. S. Life Sci.2007, 81, 1638-1644.(pdf)

  174. Investigations of the molecular mechanism of metal-induced Aβ (1-40) amyloidogenesis, Lim, K. H.; Kim, Y. K.; Chang, Y. T. Biochemistry 2007, 46, 13523-12532 (pdf) (SI).

  175. Tagged small molecule library approach for facilitated chemical genetics, Ahn, Y. H.; Chang, Y. T.* Acc. Chem. Res., 2007, 40, 1025-1033 (pdf).

  176. Styryl-based compounds as potential in vivo imaging agents for β-amyloid plaques, Li, Q.; Min, J.; Ahn, Y. H.; Namm, J.; Kim, E. M.; Lui, R.; Kim, H. Y.; Ji, Y.; Wu, H.; Wisniewski, T.; Chang, Y. T.* ChemBioChem 2007, 8, 1679-1687 (pdf) (SI).

  177. Rapid identification of immunostimulatory α-galactosylceramides using synthetic combinatorial libraries, Li, Q.; Ndonye, R. M.; Illarionov, P. A.; Yu, K. O. A.; Jerud, E. S.; Diaz, K.; Bricard, G.; Porcelli, S. A.; Besra, G. S.; Chang, Y. T.; Howell, A. R. J. Comb. Chem. 2007, 9, 1084-1093 (pdf) (SI).

  178. Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin, Min, J.; Lee, J. W.; Ahn, Y. H.; Chang, Y. T.* J. Comb. Chem. 2007, 9, 1079-1083 (pdf) (SI).

  179. Counterion free colorimetic metal cation sensor array, Lee, J. S.; Lee, J. W.; Chang, Y. T.* J. Comb. Chem. 2007, 9, 926-928 (pdf) (SI).

  180. Combinatorial rosamine library and application to in vivo glutathione probe, Ahn, Y. H.; Lee, J. S.; Chang, Y. T.* J. Am. Chem. Soc. 2007, 129, 4510-4511 (pdf) (SI).

  181. Understanding activity of small molecules in the genomic context (Highlight article), Lee, J. S.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2007, 46, 3616-3618 (pdf).

  182. Small-molecule switch for zebrafish gene expression (News and Views), Chang, Y. T.* Nat. Chem. Biol. 2007, 3, 135-136 (pdf).

  183. 중심학문으로서의 화학; 생물화학, Chang, Y. T.* 화학세계 2007, 24-31 (pdf).

  184. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling, Min, J. K.; Kim, Y. K.; Cipriani, P. G.; Kang, M.; Khersonsky, S. M.; Walsh, D. P.; Lee, J. Y.; Niessen, S.; Yates, J. R.; Gunsalus, K.; Piano, F.; Chang, Y. T.* featured article in Nat. Chem. Biol. 2007, 3, 55-59 (pdf) (SI-1, SI-2, SI-3, SI-4, SI-5, SI-6, SI-7). Highlighted at "New diabetes target, En News, 2006 (December 4), 84 (49), p63(htm) NYU, Scripps Finding Offers New Path For Treatment Of Diabetes, Medical News Today, 2006 (November 30) (htm), NYU Today (December 18) (htm).

  185. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part II. Integrase inhibition, Lee-Huang, S.; Huang, P. L.; Zhang, D.; Lee, J. W.; Bao, J.; Sun, Y.; Chang, Y. T.; Zhang, J.; Huang, P. L. Biochem. Biophys. Res. Commun. 2007, 354, 879-884 (pdf).

  186. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition, Lee-Huang, S.; Huang, P. L.; Zhang, D.; Lee, J. W.; Bao, J.; Sun, Y.; Chang, Y. T.; Zhang, J.; Huang, P. L. Biochem. Biophys. Res. Commun. 2007, 354, 872-878 (pdf).

  187. Tagged library approach facilitates forward chemical genetics, Kim, Y. K.; Chang, Y. T.* Mol. Biosyst. 2007, 3, 392-397 (pdf).

  188. A protocol for preparing, characterizing and using three RNA-specific, live cell imaging probes: E36, E144 and F22, Li, Q.; Chang, Y. T.* Nature Protocols, 2006,1, 2922-2932 (pdf).

  189. Colorimetric identification of carbohydrates by a pH indicator/ pH change inducer ensemble, Lee, J. W.; Lee, J. S.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2006, 45, 6485-6487 (pdf) (SI). Highlighted at "Discriminating between carbohydrates, C&En News, 2006 (September 25), 84 (39), p 90" (htm)

  190. Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation, Park, H. E.; Baek, S. H.; Min, J. K.; Chang, Y. T.; Kang, D. K.; Chang, S. I.; Joe, Y. A. DNA Cell Biol. 2006, 25, 514-522 (pdf).

  191. Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors, Wang, S.; Chang, Y. T.* J. Am. Chem. Soc. 2006, 128, 10380-10381 (pdf)(SI).

  192. A high throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide, Kim, W.; Kim Y. K.; Min, J. K.; Kim, D. J.; Chang, Y. T.*; Hecht, M. H.* ACS Chem. Biol. 2006, 1, 461-469 (pdf). Previewed at "From green bacteria to human dementia: a novel model for discovering amyloid assembly inhibitors, Gazit, E. ACS Chem. Biol. 2006, 1, 417-419 " (pdf).

  193. RNA-selective, live cell imaging probes for studying nuclear structure and function., Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T.* Chem. Biol. 2006, 13, 615-623 (pdf)(SI). Previwed at "Styryl molecules light-up RNAs, Dirks, R. W.; Tanke, H. J. Chem. Biol. 2006, 13, 560-561." (pdf); Highlighted at "Styryl dyes image RNA in living cells, C&En News, 2006 (July 3), 84 (27), 30 (htm)" & at "RNA dyes for life, Rothman, S. The Scientist, 2006, 20, 67 (htm)" & at "Illuminating cellular RNA, Sheppard, T. L. Nat. Chem. Biol. 2006, 2, 405 (pdf)" & at "Live and let dye, Biotechniques 2006, 41, 231 (pdf)"

  194. Visual artificial tongue for quantitative metal cation analysis by an off-the-shelf dye array, Lee, J. W.; Lee, J. S.; Kang, M.; Su, A. I.; Chang, Y. T.* Chem. Eur. J. 2006, 12, 5691-5696 (pdf) (SI).

  195. Chemical Genetics, Walsh, D. P.; Chang, Y. T.* Chem. Rev. 2006, 106, 2476-2530 (pdf).

  196. Identification of 12Cysβ on tubulin as the binding site of tubulyzine, Kim, Y. J.; Sackett, D. L.; Schapira, M.; Walsh, D. P.; Min, J.; Pannell, L. K.; Chang, Y. T.* Bioorg. Med. Chem. 2006, 14, 1169-1175 (pdf).

  197. FceRI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphate, Stokes, A. J.; Shimoda, L. M.; Lee. J. W.; Chang, Y. T.; Turner, H. Cell Signal. 2006, 18, 640-651 (pdf).

  198. Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-d-erythro-sphingosine and N-lauroyl-d-erythro-C(20)-sphingosine., Park, J.; Kim, S. H.; Li, Q.; Chang, Y. T. Kim, T. S. Biochem. Pharmacol., 2006, 71, 1229-1239 (pdf).

  199. Identification of a new class of PGT inhibitors and characterization of their biological effects on PGE2 transport, Chi, Y.; Khersonsky, S. M.; Chang, Y. T.; Schuster, V. L. J. Pharmacol. Exp. Ther. 2006, 316, 1346-1350 (pdf) (SI-1, SI-2, SI-3).

  200. Bookreview for "Methods in Pharmacology and Toxicology: Optimization in Drug Discovery: In Vitro Methods" by Zhengyun Yan and Cary W. Caldwell, Chang, Y. T. ChemBioChem 2005, 6, 1127-1130 (pdf).

  201. Small molecule microarrays: recent advances and applications, Uttamchandani, M.; Walsh, P. D.; Yao , S. Q.; Chang, Y. T.* Curr. Opin. Chem. Biol., 2005, 9, 4-13 (pdf)

  202. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression, Harding, H. P.; Zhang, Y.; Khersonsky, S.; Marciniak, S.; Javitt, N.; Chang, Y. T.; Ron, D. Cell Metab. 2005, 2, 361-371 (pdf) (SI).

  203. Triazine-based tyrosinase inhibitors identified by chemical genetic screening, Ni-Komatsu, L.; Leung, J. K.; Williams, D.; Min, J.; Khersonsky, S. M.; Chang, Y. T.; Orlow, S. J. Pigment Cell Res. 2005, 18, 447-453 (pdf).

  204. A single cell analysis of myogenic dedifferentiation induced by small molecules, Duckmanton, A.; Kumar, A.; Chang, Y. T.; Brockes, J. P. Chem. Biol. 2005, 12, 1117-1126 (pdf) (SI-1, SI-2, SI-3, SI-4).

  205. Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish, Jung, D. W.; Williams, D. Khersonsky, S. M.; Kang, T. W.; Heidary, N.; Chang, Y. T.; Orlow, S. J. Mol. Biosyst. 2005, 1, 85-92 (pdf).

  206. Phytic Acid Synthesis and Vacuolar Accumulation in Suspension-Cultured Cells of Catharanthus roseus Induced by High Concentration of Inorganic Phosphate and Cations, Mitsuhashi, N.; Ohnishi, M.; Sekiguchi, Y.; Kwon, Y. U.; Chang, Y. T.; Chung, S. K.; Inoue, Y.; Reid, R. j.; Yagisawa, H.; Mimura, T. Plant Physiol. 2005, 138, 1607-1614 (pdf)(SI).

  207. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator, Snyder, J. R.; Hall, A.; Ni-Komatsu, L.; Kherson sky , S. M.; Chang, Y. T.; Orlow, S. J. Chem. Biol. 2005, 12, 477-484 (pdf). High lighted at "Mitochondria give cells a tan, Rosania, G. R. Chem. Biol. 2005, 12, 412-413." (pdf).

  208. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides, Yu, K. O. A.; Im, J. S.; Molano, A.; Dutronc, Y.; Illarionov, P. A.; Forestier, C.; Fujiwara, N.; Arias, I.; Miyake, S.; Yamamura, T.; Chang, Y. T.; Besra, G. S.; Porcelli, S. A.  Proc. Nat. Acad. Sci. U. S. A. 2005, 102, 3383-3388 (pdf).

  209. Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity, Lee-Huang, S.; Maiorov, V.; Huang, P. L.; Ng, A.; Lee, H. C.; Chang, Y. T.; Kallenbach, N.; Huang, P. L.; Chen, H. C. Biochemistry 2005, 44, 4648-4655 (pdf).

  210. Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells, Park, J.; Li, Q.; Chang, Y. T.; Kim, T. S. Bioorg. Med. Chem. 2005, 13, 2589-2595 (pdf).

  211. Solid phase synthesis of styryl dye library and its application to amyloid sensors, Li, Q.; Lee, J. S.; Ha, C.; Park, C. B.; Yang G.; Gan, W. B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2004, 43, 6331-6335 (pdf) (SI).

  212. System dynamics of subcellular transport, Chen, V. Y.; Kherson sky , S. M.; Shedden, K.; Chang, Y. T.; Rosania, G. R. Mol. Pharm. 2004, 1, 414-425 (pdf) (SI).

  213. Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism, Williams, D.; Jung, D. W.; Kherson sky , S. M.; Heidary, N.; Chang, Y. T.; Orlow, S. J. Chem. Biol. 2004, 11, 1251-1259 (pdf).

  214. Microarrays of Tagged Combinatorial Triazine Libraries in the Discovery of Small Molecule Ligands of Human IgG, Uttamchandani, M.; Walsh, D. P.; Kherson sky , S. M.; Huang, X.; Yao, S. Q.; Chang, Y. T.* J. Comb. Chem. 2004, 6, 862-868 (pdf) (SI).

  215. Tools for target identification and validation, Wang, S.; Sim, T.; Kim, Y. S.; Chang, Y. T.* Curr. Opin. Chem. Biol. 2004, 8, 371-377 (pdf).

  216. Dedifferentiation? What's next? Kim, S.; Rosania, G. R.; Chang, Y. T.* Mol. Interv. 2004, 4, 83-85 (pdf).

  217. Forward chemical genetics: library scaffold design, Kherson sky , S. M.; Chang, Y. T.* Comb. Chem. High Throughput Screening  2004, 7, 645-652 (pdf).

  218. Strategies for facilitated forward chemical genetics, Kherson sky , S. M.; Chang, Y. T.* ChemBioChem  2004, 5, 903-908 (pdf).

  219. The combinatorial synthesis of purine, pyrimidine, and triazine-based libraries, Bork, J. T.; Lee, J. W.; Chang, Y. T.* QSAR Comb. Sci. 2004, 23, 245-260 (pdf).

  220. Recent Advances in Small Molecule Microarrays: Applications and Technology, Walsh, D. P.; Chang, Y. T.* Comb. Chem. High Throughput Screening  2004, 7, 557-564 (pdf).

  221. Tagged library approach to chemical genomics and proteomics, Mitsopoulos, G.; Walsh, D. P.; Chang, Y. T.* Curr. Opin. Chem. Biol. 2004, 8, 26-32 (pdf).

  222. Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatases Schizosaccharomyces pombe synaptojanin and SHIP2, Chi, Y.; Zhou, B.; Wang, W. Q.; Chung, S. K.; Kwon, Y. U.; Ahn, Y. H.; Chang, Y. T. Tsujishita, Y.; Hurley, J. H.; Zhang, Z. Y. J. Biol. Chem. 2004, 279, 44987-44995 (pdf).

  223. Distinctive expression of Myf5 in relation to differentiation and plasticity of newt muscle cells, Imokawa, Y.; Gates, P. B. Chang, Y. T.; Simon, H. G., Brockes, J. P. Int. J. Dev. Biol. 2004, 48, 285-291 (pdf).

  224. Molecular evolution on chiro-Inositol dibenzoate using intramolecular acyl migration and selection by phenyl boronic acid, Ahn, Y. H.; Chang, Y. T.* J. Comb. Chem. 2004, 6, 293-296 (pdf).

  225. Molecular evolution using intramolecular acyl migration on myo-Inositol benzoates with thermodynamic and kinetic selectors, Ahn, Y. H.; Chang, Y. T.* Chem. Eur. J., 2004, 10, 3543-3547 (pdf).

  226. Safety-Catch Approach to Orthogonal Synthesis of Triazine Library, Khersonsky, S. M.; Chang, Y. T.* J. Comb. Chem. 2004, 6, 474-477 (pdf).

  227. Identification of a novel protein regulating microtubule stability through a chemical approach, Wignall, S. M.; Gray, N. S.; Chang, Y. T. Juarez, L.; Jacob, R. Burlingame, A.; Schultz, P. G.; Heald, R. Chem. Biol. 2004, 11, 135-246 (pdf)(with cover picture) (SI).

  228. Chemoinformatic Analysis of a Supertargeted Combinatorial Library of Styryl Molecules, Shedden, K.; Brumer, J.; Chang, Y. T.; Rosania, G. R. J. Chem. Inf. Comput. Sci. 2003, 43, 2068-2080 (pdf).

  229. Facilitated forward chemical genetics using tagged triazine library and zebrafish embryo screening, Kherson sky , S. M; Jung, D. W.; Kang, T. W.; Walsh, D. P.; Moon, H. S.; Jo, H.; Jacobson, E. M.; Shetty, V.; Neubert, T. A.; Chang, Y. T.* J. Am. Chem. Soc. 2003, 125, 11804-11805 (pdf) (SI).

  230. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment, Lee-Huang, S.; Zhang, L.; Huang, P. L.; Chang, Y. T.; Huang, P. L. Biochem. Biophys. Res. Commun. 2003, 307, 1029-1037 (pdf).

  231. Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell based screening, Lee, J. W.; Jung, M.; Rosania, G. R.; Chang, Y. T.* ChemComm 2003, 1852-1853 (pdf) (SI).

  232. Understanding the effects of the polymer support on reaction rates and kinetics: knowledge toward efficient synthetic design, Walsh, D. P; Wu, D.; Chang, Y. T.* Curr. Opin. Chem. Biol. 2003, 7, 353-361 (pdf).

  233. Recent advances in glycomics and glycogenetics, Khersonsky, S. M.; Ho, C. M.; Garcia, M. F.; Chang, Y. T.* Curr. Topic. Med. Chem. 2003, 3, 617-643 (pdf) (with Preface: Chemical Biology and Chemical Genetics, Rosania, G. R. & Chang, Y. T. as Guest Editors).

  234. Palladium-catalyzed cross-coupling reaction of resin-bound chlorotriazines, Bork, J. T.; Lee, J. W.; Chang, Y. T.* Tetrahedron Lett. 2003, 44, 6141-6144 (pdf).

  235. Tubulyzine a novel trisubstituted triazine prevents the early cell death of transplanted myoblasts and improves myoblast transplantation success, El Fahime, E.; Bouchentouf, M.; Benabdallah, B. F.; Skuk, D.; Chang, Y. T.; Tremblay, J. P. Biochem. Cell Biol. 2003, 81, 81-90 (pdf).

  236. Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles, Shedden, K.; Xie, X. T.; Chandaroy, P.; Chang, Y. T.; Rosania, G. R. Cancer Res. 2003, 63, 4331-4337(pdf).

  237. Effects of Tubulyzines, Novel Microtubule-Binding Triazine Molecules, on Endothelial Progenitor Cell Differentiation, Park, H. E.; Lee, S. Y.; Ahn, H. Y.; Shin, J. C.; Chang, Y. T.; Joe, Y. A. J. Appl. Pharmacol. 2003, 11, 85-90 (pdf).

  238. Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold, Rosania, G. R.; Lee, J. W.; Ding, L.; Yoon, H. S.; Chang, Y. T.* J. Am. Chem. Soc. 2003,125, 1130-1131 (pdf) (SI).

  239. Novel Orthogonal Strategy toward Solid Phase Synthesis of 1,3,5-Substituted Triazines, Bork, J.; Lee, J. W.; Kherson sky , S. M.; Moon, H. S.; Chang, Y. T.* Org. Lett. 2003, 5, 117-120 (pdf) (SI).

  240. Nitrophenol resins for facile amide and sulfonamide library synthesis, Lee, J. W.; Louie, Y. Q.; Walsh, D. P.; Chang, Y. T.* J. Comb. Chem. 2003, 5, 330-335 (pdf).

  241. Single Resin Bead Kinetics Using Real Time Fluorescence Measurements, Parikh, P. B.; Kim, Y. S.; Chang, Y. T.* Bull. Korean Chem. Soc. 2002, 23, 1509-1510 (pdf).

  242. A Novel Microtubule destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening, Moon, H. S.; Jacobson, E. M.; Khersonsky, S. M.; Luzung, M. R.; Walsh, D. P.; Xiong, W.; Lee, J. W.; Parikh, P. B.; Lam, J. C.; Kang, T. W.; Rosania, G. R.; Schier, A. F.; Chang, Y. T.* J. Am. Chem. Soc. 2002, 124, 11608-11609 (pdf) (SI). High lighted at "Paper alert, Hall, D. G. Curr. Opin. Chem. Biol. 2002, 6, 719." (pdf)

  243. Purine based inhibitors of Inositol-1,4,5-trisphosphate-3-kinase, Chang, Y. T.*; Choi, G.; Bae, Y. S.; Burdett, M.; Moon, H. S.; Lee, J. W.; Gray, N. S.; Schultz, P. G.; Meijer, L.; Chung, S. K.; Choi, K. Y.; Suh, P. G.; Ryu, S. H. ChemBioChem 2002, 3, 897-901 (pdf).

  244. Divergent synthesis of all possible optically active regioisomers of myo-inositol tris- and tetrakisphosphates, Chung, S. K.; Kwon, Y. U.; Shin, J. H.; Chang, Y. T.; Lee, C. G.; Shin, B. G.; Kim, K. C.; Kim, M. J. J. Org. Chem. 2002, 67, 5626-2637 (pdf) (SI).

  245. Combinatorial Discovery of Novel Fluorescent Dyes Based on Dapoxyl™, Zhu, Q.; Yoon, H. S.; Parikh, P. B.; Chang, Y. T.; Yao, S. Q. Tetrahedron Lett. 2002, 43, 5083-5086 (pdf).

  246. Inhibition and reversal of myogenic differentiation by prine-based microtubule assembly inhibitors, Perez, O. D.; Chang, Y. T.; Rosania, G.; Sutherlin, D.; Schultz, P. G. Chem. Biol. 2002, 9, 475-483 (pdf) (with cover picture).

  247. The synthesis and biological characterization of a ceramide library, Chang, Y. T.*; Choi, J.; Ding, S.; Prieschl, E. E.; Baumruker, T.; Lee, J. M.; Chung, S. K.; Schultz, P. G. J. Am. Chem. Soc. 2002, 124, 1856-1857 (pdf) (SI).

  248. Comparative resin kinetics using in situ fluorescence measurements, Walsh, D. P.; Pang, C.; Parikh, P. B.; Kim, Y. S.; Chang, Y. T.* J. Comb. Chem. 2002, 4, 204-208 (pdf) (SI) (correction).

  249. The identification and quantification of para-phenylenediamine in a temporary black henna tattoo, Brancaccio, R. R.; Brown, L. H.; Chang, Y. T.; Fogelman, J. P.; Mafong, E. A.; Cohen, D. E. Am. J. Contact Dermatitis 2002, 13, 15-18. (pdf)

  250. (±)-1,2;5,6-Di-O-isopropylidene-myo-inositol and (±)-1,2;4,5-di-O-isopropylidene-6-O-benzoyl-myo-inositol: a practical preparation of key intermediates for myo-inositol phosphates, Kherson sky , S. M.; Chang, Y. T.* Carbohydr. Res. 2002, 337, 75-78 (pdf).

  251. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors, Chang, Y. T.*; Wignall, S. M.; Rosania, G. R.; Gray, N. S.; Hanson, S. R.; Su, A. I.; Merlie, Jr., J.; Moon, H. S.; Sangankar, S. B.; Perez, O.; Heald, R.; Schultz, P. G. J. Med. Chem. 2001, 44, 4497-4500 (pdf) (SI).

  252. Discovery of estrogen sulfotransferase inhibitors from a purine library screen, Verdugo, D. E.; Cancilla, M. T.; Ge, X.; Gray, N. S.; Chang, Y. T.; Schultz, P. G.; Negishi, M.; Leary, J. A.; Bertozzi, C. R. J. Med. Chem. 2001, 44, 2683-2686 (pdf) (SI).

  253. Inositol phospholipid pathway inhibitors and regulators, Chang, Y. T.*; Rosania, G. R.; Chung, S. K. Expert Opin. Ther. Pat. 2001, 11, 45-59 (pdf).

  254. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilized inhibitors, Knockaert, M.; Gray, N.; Damiens, E.; Chang, Y. T.; Grellier, P.; Grant, K.; Fergusson, D.; Mottram, J.; Soete, M.; Dubremetz, J. F., Le Roch K.; Doerig, C.; Schultz, P. G.; Meijer, L. Chem. Biol. 2000, 7, 411-422 (pdf).

  255. Targeting hyperproliferative disorders with cyclin dependent kinase inhibitors, Rosania, G. R.; Chang, Y. T. Expert Opin. Ther. Pat. 2000, 10, 215-230 (pdf).

  256. Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library, Armstrong, J. I.; Portley, A. R.; Chang, Y. T.; Nierengarten, D. M.; Cook, B. N.; Bowman, K. G.; Bishop, A.; Gray, N. S.; Shokat, K. M.; Schultz, P. G.; Bertozzi, C. R. Angew. Chem. Int. Ed. Engl. 2000, 39, 1303-1306 (pdf) (SI).

  257. A Novel DAST-induced Debenzylative Cycloetherization in D-1,2-O-Isopropylidene-3,4,5-tri-O-benzyl-myo-inositol, Chung, S. K.; Kwon, Y. U.; Ahn, Y. H.; Jeong, T. H.; Chang, Y. T. Bull. Korean Chem. Soc. 2000, 21, 274-276 (pdf).

  258. Myoseverin: a microtubule binding molecule with novel cellular effects, Rosania, G. R.; Chang, Y. T.; Perez, O.; Sutherlin, D.; Dong, H.; Lockhart, D. J.; Schultz, P. G. Nat. Biotechnol. 2000, 18, 304-308 (pdf) (with cover picture). High lighted at "Combinatorial chemistry gives cell biology some muscle, Hall, D. G. Nat. Biotechnol. 2000, 18, 261-262." (pdf)

  259. Versatile fluorescence labeling method using activated esters on solid support, Chang, Y. T.; Schultz, P. G. Bioorg. Med. Chem. Lett. 1999, 9, 2479-2482 (pdf).

  260. Synthesis of All Possible Regioisomers of scyllo-Inositol Phosphate, Chung, S. K.; Kwon, Y. U.; Chang, Y. T.; Sohn, K. H.; Shin, J. H.; Park, K. H.; Hong, B. J.; Chung, I. H. Bioorg. Med. Chem. 1999, 7, 2577-2589 (pdf).

  261. Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-I(3,4,5)P3, Hanck, T.; Stricker, R.; Krishna, U. M.; Falck, J. R.; Chang, Y. T.; Chung, S. K.; Reiser, G. Eur. J. Biochem. 1999, 261, 577-584 (pdf).

  262. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors, Chang, Y. T.; Gray, N.; Rosania, G. R.; Sutherlin, D. P.; Kwon, S.; Norman, T.; Sarohia, R.; Leost, M.; Meijer, L.; Schultz, P. G. Chem. Biol. 1999, 6, 361-375 (pdf) (with cover picture).

  263. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts, Rosania, G. R.; Merlie, Jr., J.; Gray, N.; Chang, Y. T.; Schultz, P. G.; Heald, R. Proc. Natl. Acad. Sci. USA 1999, 96, 4797-4802 (pdf) (SI).

  264. An Efficient Synthesis of D-myo-Inositol 1,3,4,5-tetrakisphosphate, Chung, S. K.; Chang, Y. T.; Lee, E. J.; Kwon, Y. U. Kor. J. Med. Chem. 1998, 8, 18-21 (pdf).

  265. Syntheses of Two Enantiomeric Pairs of myo-Inositol-(1,2,4,5,6) and -(1,2,3,4,5) pentakisphosphate, Chung, S. K.; Chang, Y. T.; Lee, E. J.; Shin, B. G.; Kwon, Y. U.; Kim, K. C.; Lee, D. H.; Kim, M. J. Bioorg. Med. Chem. Lett. 1998, 8, 1503-1506 (pdf).

  266. Syntheses of D- and L-myo-Inositol-1,2,4,5-tetrakisphosphate, the Stereoselectivity of I(1,4,5)P3 Receptor Recognition, Chung, S. K.; Shin, B. G.; Chang, Y. T.; Suh, B. C.; Kim, K. T. Bioorg. Med. Chem. Lett. 1998, 8, 659-662 (pdf).

  267. Syntheses of D-myo-Inositol-1,2,6-trisphosphate and -2,6-bisphosphate, Chung, S. K.; Yu, S. H.; Chang, Y. T. J. Carbohydr. Chem. 1998, 17, 385-390 (pdf).

  268. Synthesis of All Regioisomers of myo-Inositol Bisphosphates, Chung, S. K.; Chang, Y. T.; Kwon, Y. U. J. Carbohydr. Chem. 1998, 17, 369-384 (pdf).

  269. Molecular Probes for the Binding Site of Inositol 1,4,5-trisphosphate (IP3) 3-Kinase and Comparison with IP3 Receptor, Choi, G.; Chang, Y. T.; Chung, S. K.; Choi, K. Y. Kor. J. Med. Chem. 1997, 7, 106-114 (pdf).

  270. Selective Benzoylations of myo-Inositol Orthoformate and a Practical Synthesis of myo-Inositol-1,3,4,5-tetrakisphosphate, Chung, S. K.; Chang, Y. T.; Lee, J. W.; Ji, Y. K. Kor. J. Med. Chem. 1997, 7, 82-85 (pdf).

  271. Syntheses of myo-Inositol-1,2,3,5- and -2,4,5,6-tetrakisphosphates, Unusual Inhibitors of myo-Inositol-1,4,5-trisphosphate 3-Kinase, Chung, S. K.; Chang, Y. T. Bioorg. Med. Chem. Lett. 1997, 7, 2715-2718 (pdf).

  272. Molecular Interactions of All Possible Regioisomers of Synthetic myo-Inositol Phosphates with myo-Inositol-1,4,5-trisphosphate 3-Kinase, Choi, G.; Chang, Y. T.; Chung, S. K.; Choi, K. Y. Bioorg. Med. Chem. Lett. 1997, 7, 2709-2714 (pdf).

  273. Microwave Enhanced Knoevenagel Condensation of Malonic Acid on Basic Alumina, Kwon, P. S.; Kim, Y. M.; Kang, C. J.; Kwon, T. W.; Chung, S. K.; Chang, Y. T. Syn. Commun. 1997, 27, 4091-4100 (pdf).

  274. Synthesis of D-Galactopyranosyl-1,2,6-trisphosphate as a Geometric Analogue of D-myo-Inositol 1,4,5-trisphosphate, Chung, S. K.; Kwon, Y. U.; Chang, Y. T. Kor. J. Med. Chem. 1997, 7, 63-68 (pdf).

  275. Solution Conformation and Kinetic Acidity of 1,2;4,5-Di-O-isopropylidene-myo-inositol, Chung, S. K.; Chang, Y. T. Kor. J. Med. Chem. 1997, 7, 15-18 (pdf).

  276. Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes, Kim, S. Y.; Kwon, P. S.; Kwon, T. W.; Chung, S. K.; Chang, Y. T. Syn. Commun. 1997, 27, 533-541 (pdf).

  277. Theoretical Studies of Regioselectivity of myo-Inositol Derivatives: Importance of Solvent Dielectric Constants, Kim, K. S.; Cho, S. J.; Oh, K. S.; Son, J. S.; Kim, J.; Lee, J. Y.; Lee, S. J.; Lee, S.; Chang, Y. T.; Chung, S. K.; Ha, T. K.; Lee, B. S.; Lee, I. J. Phys. Chem. 1997, 101, 3776-3783 (pdf).

  278. Binding and Activity of the Nine Possible Regioisomers of myo-Inositol Tetrakisphosphate at the Inositol 1,4,5-Trisphosphate Receptor, Burford, N. T.; Nahorski, S. R.; Chung, S. K.; Chang, Y. T.; Wilcox, R. A. Cell Calcium 1997, 21, 301-310 (pdf).

  279. Rapid Kinetic Measurements of 45Ca2+ Mobilization Reveal that Inositol 2,4,5-Trisphosphate is a Partial Agonist at Hepatic Inositol Trisphosphate Receptor, Marchant, J. S.; Chang, Y. T.; Chung, S. K.; Irvine, R. F.; Taylor, C. W. Biochem. J. 1997, 321, 573-576 (pdf).

  280. Determination of Specificity of a High Affinity Inositol-1,3,4,5-tetrakisphosphate Binding Site at a 42 kD Receptor Protein: Comparison of Affinities of All Regioisomers of Inositol Tris-, Tetrakis-, and Pentakisphosphate, Stricker, R.; Chang, Y. T.; Chung, S. K.; Reiser, G. Biochem. Biophys. Res. Commun. 1996, 228, 596-604 (pdf).

  281. Synthesis of myo-Inositol-1,2,3-trisphosphate by Selective Benzylation: the Iron Binding Motif of Phytic acid (IP6), Chung, S. K.; Chang, Y. T. Kor. J. Med. Chem. 1996, 6, 253-258 (pdf).

  282. New Approach to the Synthetic Problems of myo-Inositol Phosphates and Their Biological Utilities, Chung, S. K.; Chang, Y. T.; Sohn, K. H. in "Medicinal Chemistry: Today and Tomorrow", pp 63-68, Ed. M. Yamazaki, Blackwell Science, 1996 (pdf).

  283. A Divergent Approach toward Synthesis of myo-Inositol Phosphates: Acyl Migration and Regioselectivity, Chung, S. K.; Chang, Y. T.; Ryu, Y. Pure Appl. Chem. 1996, 68, 931-935 (pdf).

  284. Synthesis of All Possible Regioisomers of myo-Inositol Monophosphate, Chung, S. K.; Chang, Y. T. Kor. J. Med. Chem. 1996, 6, 162-165 (pdf).

  285. Crystal Structures of DL-1,4-Di-O-benzoyl-2,3-O-isopropylidene-myo-inositol and DL-1,4-Di-O-benzoyl-5,6-O-isopropylidene-myo-inositol: a Conformational Analysis, Chung, S. K.; Chang, Y. T.; Whang, D.; Kim, K. Carbohydr. Res. 1996, 295, 1-6 (pdf).

  286. Synthesis of All Possible Regioisomers of myo-Inositol Pentakisphosphate, Chung, S. K.; Chang, Y. T. Bioorg. Med. Chem. Lett. 1996, 6, 2039-2042 (pdf).

  287. Ab initio Conformational Study of 1,2,;4,5-Di-O-isopropylidene-myo-inositol, Lee, S. J.; Cho, S. J.; Oh, K. S.; Cui, C.; Ryu, Y.; Chang, Y. T.; Kim, K. S.; Chung, S. K. J. Phys. Chem. 1996, 100, 10111-10115 (pdf).

  288. Synthesis and Iron Binding Studies of myo-Inositol-1,2,3-trisphosphate and DL-myo-Inositol-1,2-bisphosphate, and Iron Binding Studies of All myo-Inositol-tetrakisphosphates, Spiers, I. D.; Barker, C. J.; Chung, S. K.; Chang, Y. T.; Freeman, S.; Gardiner, J. M.; Hirst, P. H.; Lambert, P. A.; Michell, R. H.; Poyner, D. R.; Schwalbe, C. H.; Smith, A. W.; Solomons, K. R. H. Carbohydr. Res. 1996, 282, 81-99 (pdf).

  289. Practical Divergent Synthesis of All Possible Regioisomers of myo-Inositol Trisphosphates, Chung, S. K.; Chang, Y. T.; Sohn, K. H. J. Chem. Soc., Chem. Commun. 1996, 163-164 (pdf).

  290. Specificity of the Purified Inositol-1,3,4,5-tetrakisphosphate-binding Protein from Porcine Platelets, Cullen, P. J.; Chung, S. K.; Chang, Y. T.; Dawson, A. P.; Irvine, R. F. FEBS Lett. 1995, 358, 240-242 (pdf).

  291. Base-catalyzed Acyl Migration in myo-Inositol Dibenzoates, Chung, S. K.; Chang, Y. T. J. Chem. Soc., Chem. Commun. 1995, 13-14 (pdf).

  292. Synthesis of All Possible Regioisomers of myo-Inositol Tetrakisphosphates, Chung, S. K.; Chang, Y. T. J. Chem. Soc., Chem. Commun. 1995, 11-12 (pdf).

  293. Synthesis of myo-Inositol-1,4,5-, 2,4,6-, and 1,3,5-trisphosphate, Chung, S. K.; Chang, Y. T.; Sohn, K. H. Kor. J. Med. Chem. 1994, 4, 57-65 (pdf).

  294. Crystal Structure of 1,2;4,5-Di-O-isopropylidene myo-Inositol and 1,2;5,6-Di-O-isopropylidene myo-Inositol: a Conformational Analysis, Chung, S. K.; Ryu, Y.; Chang, Y. T.; Whang, D.; Kim, K. Carbohydr. Res. 1994, 253, 13-18 (pdf).

  295. Synthesis of myo-Inositol-1,4,5-trisphosphate and myo-Inositol-1,4-bisphosphate, Chung, S. K.; Ryu, Y.; Chang, Y. T.; Moon, S. H. Kor. J. Med. Chem. 1992, 2, 33-44 (pdf).

Monograph Translated

  1. In Search of Penicillin, David Wilson, Alfred A. Knopf, New York, 1976. (Chang, Y. T., translated into Korean, 1997)

Monograph

  1. Inositol phosphate-chemistry and physiology (in korean), Dae-Woo Academy Series 122, Chung, S. K.; Chang, Y. T., Seoul, Korea (1998)

  2. On-line book: Library – keyword of the post genome era (2002): http://ytchang.science.nus.edu.sg/book/html/english.html